AkilleuZ was asking for a slightly more Media-Center based way of launching games. So I've released 'My Games', which allows you to launch games from the 10' interface.
You set up your list of games in a standard Windows interface (because let's face it - you've probably had to INSTALL the darn thing using the Windows interface anyway!). You'll find the configuration app in your Start menu, under 'Program Files / Push-A-Button / My Games'.
If you have MAME installed (ideally the COMMAND line version of Mame, but the GUI version - MAME32 - will also work), you can point it to your MAME program and your rom directory, and it will scan for ROMS and add them to your list automatically.
Give it a try, tell me how it goes.
http://www.push-a-button.com.au/products/mce/MyGames.php
Author of 'EMUCenter' to play arcade classics 'MoreWithMyMusic' to sing with and normalize your Music, 'Yougle Vista' to watch YouTube, DivX & More and 'BlindTimer' to time your poker game.